Skip to content

1 Min Read Time


Collaboration with Extract Technology Takes Containment to a New Level

A customer was looking to achieve a higher level of containment in their dry granulation process as the drug they produce is highly potent and hazardous to operators. Critical to the success of the project was preserving containment during the charging, discharging and cleaning processes.

It’s all in the design detail

Fitzpatrick and Extract Technology collaborated to bring their top-quality equipment together to create the perfect solution for the customer. A Fitzpatrick CCS320 was integrated into an Extract Technology containment Isolator to deliver operator protection of <1 µg/m³.

The CCS320 was perfect for the project as it is the most compact Roll Compactor on the market and all the process parts are on the front making them easier to access.

CCS 320 Roll Compactor from FitzpatrickPart of the design requirement was that the Roll Compactor needed to be assembled and disassembled inside the isolator. Models and simulated mock-ups helped to refine the design and ensure that everything would be accessible to the operators. Consideration was made of the fact that all operations would be undertaken whilst working through glovebox ports – for instance, all connections and fasteners were reviewed for accessibility and where necessary either repositioned or specialist tools were produced. The isolator design was also altered to ensure that the access points lined up with the parts of the CCS that would need to be reached.

Rapid Transfer Ports (RTPs) are used to safely deliver fresh powder and take out the granules.

Delivering on the objective

By design the CCS320 is a very well-sealed and safe machine, complying to OEB 3 & 4 containment levels, but the addition of the isolator enabled OEB 4 & 5 to be reached. This delivered a safety guarantee for the customers’ operators but also ensured the surrounding area remained clean and contamination-free.

This aligned design has meant that full containment can be achieved at all times – even during the loading and transferring stages. Furthermore, when cleaning the equipment, this containment is preserved and the operators are able to dismantle the CCS safely through the glove ports.

If you are interested in finding out more – download the Case Study or contact one of our team to discuss how you could achieve enhanced contained systems.

Download the CASE STUDY  Discover how Fitzpatrick's Roll Compaction System  delivered both cGMP conditions and OEB 5 operator protection for a  pharmaceutical clinical production application.
Posted by Kathryn Perry
Find me on:


Blog articles direct to your inbox




Request a call back or email response

For more information, please contact our team via the form below and a representative will contact you to answer any questions. Phone inquiries can also be made +1-519-884-9660.

The Fitzpatrick Company

Our diverse process experience, world class GMP designs and engineering capabilities combine to produce equipment that meets the highest of customer expectations.

About us